By now, it's firmly established that modern humans and their Neanderthal relatives met and mated as our ancestors expanded out of Africa, resulting in a substantial amount of Neanderthal DNA scattered throughout our genome. Less widely recognized is that some of the Neanderthal genomes we've seen have pieces of modern human DNA as well.
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Cosmic rays hit computer RAM all the time. If your RAM is not ECC protected, it will likely flip a random bit. A single bit in billions of bits. Does it matter? Yes. Yes it does.